Creating the next generation of highly detailed human brain models by building on the BigBrain - the first openly accessible, microscopic resolution 3D model of the human brain.

News About the BigBrain

BigBrain Workshop 2025 Livestream

date: Oct 27

This is the link to the Youtube Livestream of the 9th BigBrain Workshop.

go to Youtube

Women in Science Award for Casey Paquola

date: Sept 19, 2025

Congratulations to Casey on receiving the prestigious For Women in Science Award, presented by L’Oréal together with the German UNESCO Commission and the German Humboldt Network.

Featured Video from 8th BigBrain Workshop 2024

date: Sept 15, 2025

This video features "EEG Simulation through Integration of Structural Connectivity Data and High-Density Surface Meshes in Brain Region-Specific Network Models" by Alejandro Salinas-Medina.

watch video

9th BigBrain Workshop

date: Aug 28, 2025

Join us in Berlin for the 9th BigBrain Workshop and connect with an outstanding lineup of speakers: Helen Zhou, Kâmil Uludağ, Andreas Horn, Petra Ritter, Dagmar Kainmüller.

HIBALL team at OHBM 2025

date: July 14, 2025

The HIBALL team met at OHBM 2025 in Brisbane and presented the BigBrain together with the Julich Brain Atlas

go to HBM site

Alan Evans appointed to the Order of Canada

date: July 03, 2025

Congratulations to Alan Evans for his appointment to the Order of Canada.

BigBrain Project Channel

date: May 8, 2025

Please visit the BigBrain Project channel on Youtube. There you will find a library of recordings from events as well as demonstrations of the tools.

go to channel

9th BigBrain Workshop

date: Mar 20, 2025

You are cordially invited to attend the 9th BigBrain Workshop, taking place in Berlin, Germany, on October 28 and 29, 2025.

Abstract submissions are now open.

Featured Paper: Integrating brainstem and cortical functional architectures

date: Jan 31, 2025

In this study (“Integrating brainstem and cortical functional architectures”), we sought out to understand the functional interplay between the cortex and brainstem in awake humans.

Full dataset over 1TB

Scans at 20μm resolution

Multiple formats

An expanding brain atlas

A thriving community

What People Say About the BigBrain

Why create the BigBrain

A message from Dr. Zilles

the major advantage of the BigBrain for our work is that the image data of the human brain are registered as a 3D volume at very high spatial resolution. Since the human brain is folded, any part of the cortical ribbon may be subjected to the geometrical effects of this folding, i.e. the cortex is obliquely or even tangentially sectioned at various sites in a 2D representation, e.g. in images of single microtome sections. This effect hampers the measurement of any cortical structure which is bound to the 3D columnar architecture of the cortex. In contrast, the BigBrain allows analyses in 3D, and thus has opened the door to many studies which would not be possible in 2D representations.

Martha Crago

Vice-Principal (Research + Innovation) McGill University

With HIBALL the partnership between two world-leading research institutions in computational neuroscience will provide an important platform for the scientists to conduct innovative, interdisciplinary, and complementary research in a rich and collaborative setting.

Yoshua Bengio

Mila Scientific Director, Quebec Artificial Intelligence Institute

HIBALL assembles a team with world-leading expertise in neuroimaging, artificial intelligence, neuroscience and neuroinformatics, which complements well the team at Mila. The active participation of several PIs with ties to Mila is very exciting, and we anticipate this lab will further expand the collaboration between neuroscience and AI experts in the Montreal ecosystem, leading to cutting-edge discoveries in both fields.

Viktor Jirsa

Directeur de Recherche, CNRS

HIBALL can build on a remarkable expertise and international reputation and will lead to high impact contributions in Human Brain Atlasing, Neuroinformatics, and Machine Learning.